1pyd

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[[Image:1pyd.jpg|left|200px]]
[[Image:1pyd.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1pyd |SIZE=350|CAPTION= <scene name='initialview01'>1pyd</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1pyd", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TDP:THIAMIN+DIPHOSPHATE'>TDP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyruvate_decarboxylase Pyruvate decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.1 4.1.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1pyd| PDB=1pyd | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pyd OCA], [http://www.ebi.ac.uk/pdbsum/1pyd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pyd RCSB]</span>
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}}
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'''CATALYTIC CENTERS IN THE THIAMIN DIPHOSPHATE DEPENDENT ENZYME PYRUVATE DECARBOXYLASE AT 2.4 ANGSTROMS RESOLUTION'''
'''CATALYTIC CENTERS IN THE THIAMIN DIPHOSPHATE DEPENDENT ENZYME PYRUVATE DECARBOXYLASE AT 2.4 ANGSTROMS RESOLUTION'''
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[[Category: Dyda, F.]]
[[Category: Dyda, F.]]
[[Category: Furey, W.]]
[[Category: Furey, W.]]
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[[Category: lyase(carbon-carbon)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:38:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:06:18 2008''
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Revision as of 02:38, 3 May 2008

Image:1pyd.jpg

Template:STRUCTURE 1pyd

CATALYTIC CENTERS IN THE THIAMIN DIPHOSPHATE DEPENDENT ENZYME PYRUVATE DECARBOXYLASE AT 2.4 ANGSTROMS RESOLUTION


Overview

The crystal structure of brewers' yeast pyruvate decarboxylase, a thiamin diphosphate dependent alpha-keto acid decarboxylase, has been determined to 2.4-A resolution. The homotetrameric assembly contains two dimers, exhibiting strong intermonomer interactions within each dimer but more limited ones between dimers. Each monomeric subunit is partitioned into three structural domains, all folding according to a mixed alpha/beta motif. Two of these domains are associated with cofactor binding, while the other is associated with substrate activation. The catalytic centers containing both thiamin diphosphate and Mg(II) are located deep in the intermonomer interface within each dimer. Amino acids important in cofactor binding and likely to participate in catalysis and substrate activation are identified.

About this Structure

1PYD is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Catalytic centers in the thiamin diphosphate dependent enzyme pyruvate decarboxylase at 2.4-A resolution., Dyda F, Furey W, Swaminathan S, Sax M, Farrenkopf B, Jordan F, Biochemistry. 1993 Jun 22;32(24):6165-70. PMID:8512926 Page seeded by OCA on Sat May 3 05:38:30 2008

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