1pzd
From Proteopedia
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'''Structural Identification of a conserved appendage domain in the carboxyl-terminus of the COPI gamma-subunit.''' | '''Structural Identification of a conserved appendage domain in the carboxyl-terminus of the COPI gamma-subunit.''' | ||
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[[Category: Hoffman, G R.]] | [[Category: Hoffman, G R.]] | ||
[[Category: Rahl, P B.]] | [[Category: Rahl, P B.]] | ||
| - | [[Category: | + | [[Category: Appendage domain]] |
| - | [[Category: | + | [[Category: Ear domain]] |
| - | [[Category: | + | [[Category: Platform domain]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:40:36 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 02:40, 3 May 2008
Structural Identification of a conserved appendage domain in the carboxyl-terminus of the COPI gamma-subunit.
Overview
The formation of coated vesicles is a fundamental step in many intracellular trafficking pathways. COPI and clathrin represent two important and distinct sets of vesicle coating machinery, involved primarily in mediating intra-Golgi and endocytic transport, respectively. Here we identify an important functional region at the carboxyl terminus of the gamma subunit of the COPI complex (gammaCOP) and describe the X-ray crystal structure of this domain at 2.3 A resolution. This domain of gammaCOP exhibits unexpected structural similarity to the carboxyl-terminal appendage domains of the alpha and beta subunits of the AP2 adaptor proteins, integral components of clathrin-coated vesicles. The remarkable structural conservation exhibited by the gammaCOP appendage domain, coupled with functional data and primary sequence analysis, supports a model of COPI function with significant structural and mechanistic parallels to vesicular transport by the clathrin/AP2 system.
About this Structure
1PZD is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
Conserved structural motifs in intracellular trafficking pathways: structure of the gammaCOP appendage domain., Hoffman GR, Rahl PB, Collins RN, Cerione RA, Mol Cell. 2003 Sep;12(3):615-25. PMID:14527408 Page seeded by OCA on Sat May 3 05:40:36 2008
