1amx

<table><tr><td colspan='2'>[[1amx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AMX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1AMX FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1amx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1amx OCA], [http://pdbe.org/1amx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1amx RCSB], [http://www.ebi.ac.uk/pdbsum/1amx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1amx ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/CNA_STAAU CNA_STAAU]] Mediates attachment of staphylococcal cells to collagen-containing substrata.

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== Publication Abstract from PubMed ==

The crystal structure of the recombinant 19,000 M(r) binding domain from the Staphylococcus aureus collagen adhesin has been determined at 2 A resolution. The domain fold is a jelly-roll, composed of two antiparallel beta-sheets and two short alpha-helices. Triple-helical collagen model probes were used in a systematic docking search to identify the collagen-binding site. A groove on beta-sheet I exhibited the best surface complementarity to the collagen probes. This site partially overlaps with the peptide sequence previously shown to be critical for collagen binding. Recombinant proteins containing single amino acid mutations designed to disrupt the surface of the putative binding site exhibited significantly lower affinities for collagen. Here we present a structural perspective for the mode of collagen binding by a bacterial surface protein.

Structure of the collagen-binding domain from a Staphylococcus aureus adhesin.,Symersky J, Patti JM, Carson M, House-Pompeo K, Teale M, Moore D, Jin L, Schneider A, DeLucas LJ, Hook M, Narayana SV Nat Struct Biol. 1997 Oct;4(10):833-8. PMID:9334749<ref>PMID:9334749</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Narayana, S]]

[[Category: Symersky, J]]

[[Category: Bacterial adhesin]]

[[Category: Mscramm]]