1ayr

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ayr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ayr OCA], [https://pdbe.org/1ayr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ayr RCSB], [https://www.ebi.ac.uk/pdbsum/1ayr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ayr ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/ARRS_BOVIN ARRS_BOVIN]] Note=S-antigen induces autoimmune uveitis.

[[https://www.uniprot.org/uniprot/ARRS_BOVIN ARRS_BOVIN]] Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase. Isoform B plays a role in the phototransduction cascade.

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

Retinal arrestin is the essential protein for the termination of the light response in vertebrate rod outer segments. It plays an important role in quenching the light-induced enzyme cascade by its ability to bind to phosphorylated light-activated rhodopsin (P-Rh*). Arrestins are found in various G-protein-coupled amplification cascades. Here we report on the three-dimensional structure of bovine arrestin (relative molecular mass, 45,300) at 3.3 A resolution. The crystal structure comprises two domains of antiparallel beta-sheets connected through a hinge region and one short alpha-helix on the back of the amino-terminal fold. The binding region for phosphorylated light-activated rhodopsin is located at the N-terminal domain, as indicated by the docking of the photoreceptor to the three-dimensional structure of arrestin. This agrees with the interpretation of binding studies on partially digested and mutated arrestin.

X-ray crystal structure of arrestin from bovine rod outer segments.,Granzin J, Wilden U, Choe HW, Labahn J, Krafft B, Buldt G Nature. 1998 Feb 26;391(6670):918-21. PMID:9495348<ref>PMID:9495348</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 1ayr" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Bueldt, G]]

[[Category: Choe, H W]]

[[Category: Granzin, J]]

[[Category: Krafft, B]]

[[Category: Labahn, J]]

[[Category: Wilden, U]]

[[Category: Sensory transduction]]