1btn

<table><tr><td colspan='2'>[[1btn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BTN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1BTN FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MUSSPNA.GBROD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1btn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1btn OCA], [http://pdbe.org/1btn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1btn RCSB], [http://www.ebi.ac.uk/pdbsum/1btn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1btn ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/SPTB2_MOUSE SPTB2_MOUSE]] Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

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== Publication Abstract from PubMed ==

Phosphatidylinositol bisphosphate has been found to bind specifically to pleckstrin homology (PH) domains that are commonly present in signalling proteins but also found in cytoskeleton. We have studied the complexes of the beta-spectrin PH domain and soluble inositol phosphates using both circular dichroism and nuclear magnetic resonance spectroscopy, and X-ray crystallography. The specific binding site is located in the centre of a positively charged surface patch of the domain. The presence of 4,5-bisphosphate group on the inositol ring is critical for binding. In the crystal structure that has been determined at 2.0 A resolution, inositol-1,4,5-trisphosphate is bound with salt bridges and hydrogen bonds through these phosphate groups whereas the 1-phosphate group is mostly solvent-exposed and the inositol ring has virtually no interactions with the protein. We propose a model in which PH domains are involved in reversible anchoring of proteins to membranes via their specific binding to phosphoinositides. They could also participate in a response to a second messenger such as inositol trisphosphate, organizing cross-roads in cellular signalling.

Structure of the binding site for inositol phosphates in a PH domain.,Hyvonen M, Macias MJ, Nilges M, Oschkinat H, Saraste M, Wilmanns M EMBO J. 1995 Oct 2;14(19):4676-85. PMID:7588597<ref>PMID:7588597</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1btn" style="background-color:#fffaf0;"></div>

*[[Spectrin|Spectrin]]

[[Category: Lk3 transgenic mice]]

[[Category: Hyvoenen, M]]

[[Category: Saraste, M]]

[[Category: Wilmanns, M]]

[[Category: Signal transduction protein]]