1pzu

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[[Image:1pzu.gif|left|200px]]
[[Image:1pzu.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1pzu |SIZE=350|CAPTION= <scene name='initialview01'>1pzu</scene>, resolution 3.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1pzu", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= NFAT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1pzu| PDB=1pzu | SCENE= }}
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|RELATEDENTRY=[[1a02|1A02]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pzu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pzu OCA], [http://www.ebi.ac.uk/pdbsum/1pzu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pzu RCSB]</span>
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}}
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'''An asymmetric NFAT1-RHR homodimer on a pseudo-palindromic, Kappa-B site'''
'''An asymmetric NFAT1-RHR homodimer on a pseudo-palindromic, Kappa-B site'''
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[[Category: Rao, A.]]
[[Category: Rao, A.]]
[[Category: Sliz, P.]]
[[Category: Sliz, P.]]
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[[Category: human il8 promoter]]
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[[Category: Human il8 promoter]]
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[[Category: nfat1-rhr homodimer]]
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[[Category: Nfat1-rhr homodimer]]
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[[Category: protein-dna complex]]
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[[Category: Protein-dna complex]]
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[[Category: transcription factor]]
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[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:41:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:06:51 2008''
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Revision as of 02:41, 3 May 2008

Image:1pzu.gif

Template:STRUCTURE 1pzu

An asymmetric NFAT1-RHR homodimer on a pseudo-palindromic, Kappa-B site


Overview

The crystal structure of the NFAT1 Rel homology region (RHR) bound to a pseudo-palindromic DNA site reveals an asymmetric dimer interaction between the RHR-C domains, unrelated to the contact seen in Rel dimers such as NF kappa B. Binding studies with a form of the NFAT1 RHR defective in the dimer contact show loss of cooperativity and demonstrate that the same interaction is present in solution. The structure we have determined may correspond to a functional NFAT binding mode at palindromic sites of genes induced during the anergic response to weak TCR signaling.

About this Structure

1PZU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

An asymmetric NFAT1 dimer on a pseudo-palindromic kappa B-like DNA site., Jin L, Sliz P, Chen L, Macian F, Rao A, Hogan PG, Harrison SC, Nat Struct Biol. 2003 Oct;10(10):807-11. Epub 2003 Aug 31. PMID:12949491 Page seeded by OCA on Sat May 3 05:41:32 2008

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