1dlc
From Proteopedia
(Difference between revisions)
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<StructureSection load='1dlc' size='340' side='right'caption='[[1dlc]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='1dlc' size='340' side='right'caption='[[1dlc]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1dlc]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DLC FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1dlc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thuringiensis Bacillus thuringiensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DLC FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlc OCA], [https://pdbe.org/1dlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dlc RCSB], [https://www.ebi.ac.uk/pdbsum/1dlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dlc ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dlc OCA], [https://pdbe.org/1dlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dlc RCSB], [https://www.ebi.ac.uk/pdbsum/1dlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dlc ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CR3AA_BACTT CR3AA_BACTT] Promotes colloidosmotic lysis by binding to the midgut epithelial cells of Coleoptera. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dlc ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dlc ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The structure of the delta-endotoxin from Bacillus thuringiensis subsp. tenebrionis that is specifically toxic to Coleoptera insects (beetle toxin) has been determined at 2.5 A resolution. It comprises three domains which are, from the N- to C-termini, a seven-helix bundle, a three-sheet domain, and a beta sandwich. The core of the molecule encompassing all the domain interfaces is built from conserved sequence segments of the active delta-endotoxins. Therefore the structure represents the general fold of this family of insecticidal proteins. The bundle of long, hydrophobic and amphipathic helices is equipped for pore formation in the insect membrane, and regions of the three-sheet domain are probably responsible for receptor binding. | ||
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| - | Crystal structure of insecticidal delta-endotoxin from Bacillus thuringiensis at 2.5 A resolution.,Li JD, Carroll J, Ellar DJ Nature. 1991 Oct 31;353(6347):815-21. PMID:1658659<ref>PMID:1658659</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1dlc" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Delta-endotoxin|Delta-endotoxin]] | *[[Delta-endotoxin|Delta-endotoxin]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Bacillus thuringiensis]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Li | + | [[Category: Li J]] |
| - | + | ||
Current revision
CRYSTAL STRUCTURE OF INSECTICIDAL DELTA-ENDOTOXIN FROM BACILLUS THURINGIENSIS AT 2.5 ANGSTROMS RESOLUTION
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