1q0p

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[[Image:1q0p.gif|left|200px]]
[[Image:1q0p.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1q0p |SIZE=350|CAPTION= <scene name='initialview01'>1q0p</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1q0p", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alternative-complement-pathway_C3/C5_convertase Alternative-complement-pathway C3/C5 convertase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.47 3.4.21.47] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= BF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1q0p| PDB=1q0p | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q0p OCA], [http://www.ebi.ac.uk/pdbsum/1q0p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q0p RCSB]</span>
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}}
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'''A domain of Factor B'''
'''A domain of Factor B'''
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[[Category: Bhattacharya, A A.]]
[[Category: Bhattacharya, A A.]]
[[Category: Liddington, R C.]]
[[Category: Liddington, R C.]]
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[[Category: a domain]]
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[[Category: A domain]]
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[[Category: factor b]]
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[[Category: Factor b]]
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[[Category: i domain]]
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[[Category: I domain]]
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[[Category: mac-1]]
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[[Category: Mac-1]]
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[[Category: von willebrand factor]]
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[[Category: Von willebrand factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:43:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:07:11 2008''
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Revision as of 02:43, 3 May 2008

Image:1q0p.gif

Template:STRUCTURE 1q0p

A domain of Factor B


Contents

Overview

Complement factor B is a 90 kDa protein consisting of three domains: a three-module complement control protein, a von Willebrand factor A domain, and a C-terminal serine protease (SP) domain that adopts a default inactive (zymogen) conformation. The interaction between factor B and pathogen-bound C3b is mediated by its A domain, triggering a conformational change in factor B that ultimately creates the "C3 convertase" of the alternative complement pathway. We report the crystal structure of the A domain from factor B and show that it contains an integrin-like MIDAS motif that adopts the "open" conformation typical of integrin-ligand complexes, with an acidic residue (provided by a fortuitous crystal contact) completing the coordination of the metal ion. Modeling studies indicate that the factor B A domain can also adopt the closed conformation, supporting the hypothesis that an "integrin-like switch" is conserved in complement proteins and perhaps in 60 other A domains found within the human proteome.

Disease

Known disease associated with this structure: Macular degeneration, age-related, reduced risk of OMIM:[138470]

About this Structure

1Q0P is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation., Bhattacharya AA, Lupher ML Jr, Staunton DE, Liddington RC, Structure. 2004 Mar;12(3):371-8. PMID:15016353 Page seeded by OCA on Sat May 3 05:43:21 2008

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OCA

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