1rz4

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Revision as of 17:02, 12 November 2007

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spinqualitylabelsall models 1rz4, resolution 2.1Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Crystal Structure of Human eIF3k

Overview

eIF3k, the smallest subunit of eukaryotic initiation factor 3 (eIF3), interacts with several other subunits of eIF3 and the 40 S ribosomal, subunit. eIF3k is conserved among high eukaryotes, including mammals, insects, and plants, and it is ubiquitously expressed in human tissues., Interestingly, eIF3k does not exist in some species of yeast. Thus, eIF3k, may play a unique regulatory role in higher organisms. Here we report the, crystal structure of human eIF3k, the first high-resolution structure of, an eIF3 component. This novel structure contains two distinct domains, a, HEAT (named for Huntington, elongation factor 3, A subunit of protein, phosphatase 2A, target of rapamycin) repeat-like HAM (HEAT analogous, motif) domain and a winged-helix-like WH domain. Through structural, comparison and sequence conservation analysis, we show that eIF3k has, three putative protein-binding surfaces and has potential RNA binding, activity. The structure provides key information for understanding the, structure and function of the eIF3 complex.

About this Structure

1RZ4 is a Single protein structure of sequence from Homo sapiens with SO4 as ligand. Full crystallographic information is available from OCA.

Reference

Crystal structure of human eIF3k, the first structure of eIF3 subunits., Wei Z, Zhang P, Zhou Z, Cheng Z, Wan M, Gong W, J Biol Chem. 2004 Aug 13;279(33):34983-90. Epub 2004 Jun 4. PMID:15180986

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