1g2n

<table><tr><td colspan='2'>[[1g2n]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chloridea_virescens Chloridea virescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1G2N OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1G2N FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPH:L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE'>EPH</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">USP LOCUS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7102 Chloridea virescens])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1g2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1g2n OCA], [http://pdbe.org/1g2n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1g2n RCSB], [http://www.ebi.ac.uk/pdbsum/1g2n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1g2n ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The major postembryonic developmental events happening in insect life, including molting and metamorphosis, are regulated and coordinated temporally by pulses of ecdysone. The biological activity of this steroid hormone is mediated by two nuclear receptors: the ecdysone receptor (EcR) and the Ultraspiracle protein (USP). The crystal structure of the ligand-binding domain from the lepidopteran Heliothis virescens USP reported here shows that the loop connecting helices H1 and H3 precludes the canonical agonist conformation. The key residues that stabilize this unique loop conformation are strictly conserved within the lepidopteran USP family. The presence of an unexpected bound ligand that drives an unusual antagonist conformation confirms the induced-fit mechanism accompanying the ligand binding. The ligand-binding pocket exhibits a retinoid X receptor-like anchoring part near a conserved arginine, which could interact with a USP ligand functional group. The structure of this receptor provides the template for designing inhibitors, which could be utilized as a novel type of environmentally safe insecticides.

Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects.,Billas IM, Moulinier L, Rochel N, Moras D J Biol Chem. 2001 Mar 9;276(10):7465-74. Epub 2000 Oct 26. PMID:11053444<ref>PMID:11053444</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Chloridea virescens]]

[[Category: Billas, I M.L]]

[[Category: Moras, D]]

[[Category: Moulinier, L]]

[[Category: Rochel, N]]

[[Category: Structural proteomics in europe]]