1rzk
From Proteopedia
(New page: 200px<br /> <applet load="1rzk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rzk, resolution 2.90Å" /> '''HIV-1 YU2 GP120 ENV...) |
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[[Category: complex (hiv envelope protein/cd4/fab); hiv-1 exterior envelope gp120 from laboratory-adapted isolate; hxbc2; surface t-cell glycoprotein cd4; antigen-binding fragment of human immunoglobulin 17b]] | [[Category: complex (hiv envelope protein/cd4/fab); hiv-1 exterior envelope gp120 from laboratory-adapted isolate; hxbc2; surface t-cell glycoprotein cd4; antigen-binding fragment of human immunoglobulin 17b]] | ||
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Revision as of 17:02, 12 November 2007
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HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B
Overview
The conserved surface of the HIV-1 gp120 envelope glycoprotein that binds, to the HIV-1 coreceptor is protected from humoral recognition by multiple, layers of camouflage. Here we present sequence and genomic analyses for 12, antibodies that pierce these defenses and determine the crystal structures, of 5. The data reveal mechanisms and atomic-level details for three, unusual immune features: posttranslational mimicry of coreceptor by, tyrosine sulfation of antibody, an alternative molecular mechanism, controlling such sulfation, and highly selective V(H)-gene usage. When, confronted by extraordinary viral defenses, the immune system unveils, novel adaptive capabilities, with tyrosine sulfation enhancing the, vocabulary of antigen recognition.
About this Structure
1RZK is a Single protein structure of sequence from Homo sapiens and Human immunodeficiency virus 1 with NDG and NAG as ligands. Full crystallographic information is available from OCA.
Reference
Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120., Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD, Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2706-11. Epub 2004 Feb 23. PMID:14981267
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Categories: Homo sapiens | Human immunodeficiency virus 1 | Single protein | Choe, H. | Dimitrov, D.S. | Farzan, M. | Hendrickson, W.A. | Huang, C.C. | Kwong, P.D. | Majeed, S. | Moore, M.J. | Phogat, S. | Robinson, J. | Sodroski, J. | Venturi, M. | Wyatt, R. | Zhang, M.Y. | NAG | NDG | Complex (hiv envelope protein/cd4/fab); hiv-1 exterior envelope gp120 from laboratory-adapted isolate; hxbc2; surface t-cell glycoprotein cd4; antigen-binding fragment of human immunoglobulin 17b
