1jes
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1jes]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JES FirstGlance]. <br> | <table><tr><td colspan='2'>[[1jes]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JES FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=DPY:2-DEOXYRIBOFURANOSYL-PYRIDINE-2,6-DICARBOXYLIC+ACID-5-MONOPHOSPHATE'>DPY</scene>, <scene name='pdbligand=DRP:2-DEOXYRIBOFURANOSYL-PYRIDINE-5-MONOPHOSPHATE'>DRP</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=DPY:2-DEOXYRIBOFURANOSYL-PYRIDINE-2,6-DICARBOXYLIC+ACID-5-MONOPHOSPHATE'>DPY</scene>, <scene name='pdbligand=DRP:2-DEOXYRIBOFURANOSYL-PYRIDINE-5-MONOPHOSPHATE'>DRP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jes OCA], [https://pdbe.org/1jes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jes RCSB], [https://www.ebi.ac.uk/pdbsum/1jes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jes ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jes OCA], [https://pdbe.org/1jes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jes RCSB], [https://www.ebi.ac.uk/pdbsum/1jes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jes ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Stable and selective DNA base pairing by metal coordination was recently demonstrated with nucleotides containing complementary pyridine-2,6-dicarboxylate (Dipic) and pyridine (Py) bases (Meggers, E.; Holland, P. L.; Tolman; W. B.; Romesberg, F. E.; Schultz, P. G. J. Am. Chem. Soc. 2000, 122, 10714-10715). To understand the structural consequences of introducing this novel base pair into DNA we have solved the crystal structure of a duplex containing the metallo-base pair. The structure shows that the bases pair as designed, but in a Z-DNA conformation. The structure also provides a structural explanation for the B- to Z-DNA transition in this duplex. Further solution studies demonstrate that the metallo-base pair is compatible with Z- or B-DNA conformations, depending on the duplex sequence. | ||
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| - | Structure of a copper-mediated base pair in DNA.,Atwell S, Meggers E, Spraggon G, Schultz PG J Am Chem Soc. 2001 Dec 12;123(49):12364-7. PMID:11734038<ref>PMID:11734038</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 1jes" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal Structure of a Copper-Mediated Base Pair in DNA
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