1jqq

<table><tr><td colspan='2'>[[1jqq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JQQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JQQ FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jqq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jqq OCA], [https://pdbe.org/1jqq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jqq RCSB], [https://www.ebi.ac.uk/pdbsum/1jqq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jqq ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/PEX13_YEAST PEX13_YEAST]] Component of the peroxisomal translocation machinery with PEX14 and PEX17. Interacts with the PTS1 receptor (PAS10/PEX5).

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

While the function of most small signaling domains is confined to binary ligand interactions, the peroxisomal Pex13p SH3 domain has the unique capacity of binding to two different ligands, Pex5p and Pex14p. We have used this domain as a model to decipher its structurally independent ligand binding sites. By the combined use of X-ray crystallography, NMR spectroscopy, and circular dichroism, we show that the two ligands bind in unrelated conformations to patches located at opposite surfaces of this SH3 domain. Mutations in the Pex13p SH3 domain that abolish interactions within the Pex13p-Pex5p interface specifically impair PTS1-dependent protein import into yeast peroxisomes.

Topography for independent binding of alpha-helical and PPII-helical ligands to a peroxisomal SH3 domain.,Douangamath A, Filipp FV, Klein AT, Barnett P, Zou P, Voorn-Brouwer T, Vega MC, Mayans OM, Sattler M, Distel B, Wilmanns M Mol Cell. 2002 Nov;10(5):1007-17. PMID:12453410<ref>PMID:12453410</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 1jqq" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Atcc 18824]]

[[Category: Barnett, P]]

[[Category: Distel, B]]

[[Category: Douangamath, A]]

[[Category: Mayans, O]]

[[Category: Wilmanns, M]]

[[Category: Protein transport]]