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1q3a

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[[Image:1q3a.jpg|left|200px]]
[[Image:1q3a.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1q3a |SIZE=350|CAPTION= <scene name='initialview01'>1q3a</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1q3a", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NGH:N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL+HYDROXAMIC+ACID'>NGH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Stromelysin_2 Stromelysin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.22 3.4.24.22] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= MMP10 OR STMY2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1q3a| PDB=1q3a | SCENE= }}
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|RELATEDENTRY=[[1g49|1G49]], [[1bqo|1BQO]], [[1d5j|1D5J]], [[1d8f|1D8F]], [[1uea|1UEA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3a OCA], [http://www.ebi.ac.uk/pdbsum/1q3a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q3a RCSB]</span>
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}}
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'''Crystal structure of the catalytic domain of human matrix metalloproteinase 10'''
'''Crystal structure of the catalytic domain of human matrix metalloproteinase 10'''
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[[Category: Mangani, S.]]
[[Category: Mangani, S.]]
[[Category: Terni, B.]]
[[Category: Terni, B.]]
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[[Category: hydroxamic acid]]
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[[Category: Hydroxamic acid]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: metalloproteinase]]
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[[Category: Metalloproteinase]]
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[[Category: mmp-10]]
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[[Category: Mmp-10]]
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[[Category: nngh]]
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[[Category: Nngh]]
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[[Category: stromelysin-2]]
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[[Category: Stromelysin-2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:48:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:08:13 2008''
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Revision as of 02:48, 3 May 2008

Image:1q3a.jpg

Template:STRUCTURE 1q3a

Crystal structure of the catalytic domain of human matrix metalloproteinase 10


Overview

The catalytic domain of matrix metalloproteinase-10 (MMP-10) has been expressed in Escherichia coli and its crystal structure solved at 2.1 A resolution. The availability of this structure allowed us to critically examine the small differences existing between the catalytic domains of MMP-3 and MMP-10, which show the highest sequence identity among all MMPs. Furthermore, the binding mode of N-isobutyl-N-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid (NNGH), which is one of the most known commercial inhibitors of MMPs, is described for the first time.

About this Structure

1Q3A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of human matrix metalloproteinase 10., Bertini I, Calderone V, Fragai M, Luchinat C, Mangani S, Terni B, J Mol Biol. 2004 Feb 20;336(3):707-16. PMID:15095982 Page seeded by OCA on Sat May 3 05:48:47 2008

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