1q3f

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[[Image:1q3f.gif|left|200px]]
[[Image:1q3f.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1q3f |SIZE=350|CAPTION= <scene name='initialview01'>1q3f</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1q3f", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=NRI:PHOSPHORIC+ACID+MONO-(4-HYDROXY-PYRROLIDIN-3-YLMETHYL)+ESTER'>NRI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=URA:URACIL'>URA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= UNG OR DGU OR UNG15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1q3f| PDB=1q3f | SCENE= }}
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|RELATEDENTRY=[[1emh|1EMH]], [[1ssp|1SSP]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q3f OCA], [http://www.ebi.ac.uk/pdbsum/1q3f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q3f RCSB]</span>
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}}
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'''Uracil DNA glycosylase bound to a cationic 1-aza-2'-deoxyribose-contianing DNA'''
'''Uracil DNA glycosylase bound to a cationic 1-aza-2'-deoxyribose-contianing DNA'''
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[[Category: Seiple, L A.]]
[[Category: Seiple, L A.]]
[[Category: Stivers, J T.]]
[[Category: Stivers, J T.]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: udg]]
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[[Category: Udg]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:49:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:08:15 2008''
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Revision as of 02:49, 3 May 2008

Image:1q3f.gif

Template:STRUCTURE 1q3f

Uracil DNA glycosylase bound to a cationic 1-aza-2'-deoxyribose-contianing DNA


Overview

The DNA repair enzyme uracil DNA glycosylase has been crystallized with a cationic 1-aza-2'-deoxyribose-containing DNA that mimics the ultimate transition state of the reaction in which the water nucleophile attacks the anomeric center of the oxacarbenium ion-uracil anion reaction intermediate. Comparison with substrate and product structures, and the previous structure of the intermediate determined by kinetic isotope effects, reveals an exquisite example of geometric strain, least atomic motion, and electrophile migration in biological catalysis. This structure provides a rare opportunity to reconstruct the detailed structural transformations that occur along an enzymatic reaction coordinate.

About this Structure

1Q3F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Electrostatic guidance of glycosyl cation migration along the reaction coordinate of uracil DNA glycosylase., Bianchet MA, Seiple LA, Jiang YL, Ichikawa Y, Amzel LM, Stivers JT, Biochemistry. 2003 Nov 4;42(43):12455-60. PMID:14580190 Page seeded by OCA on Sat May 3 05:49:10 2008

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OCA

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