3ja4

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3ja4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori_cypovirus_1 Bombyx mori cypovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JA4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3ja4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bombyx_mori_cypovirus_1 Bombyx mori cypovirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JA4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JA4 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ja5|3ja5]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ja4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ja4 OCA], [https://pdbe.org/3ja4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ja4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ja4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ja4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ja4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ja4 OCA], [https://pdbe.org/3ja4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ja4 RCSB], [https://www.ebi.ac.uk/pdbsum/3ja4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ja4 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q6RJR5_CPVBM Q6RJR5_CPVBM]
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Double-stranded RNA (dsRNA) viruses possess a segmented dsRNA genome and a number of RNA-dependent RNA polymerases (RdRps) enclosed in a capsid. Until now, the precise structures of genomes and RdRps within the capsids have been unknown. Here we report the structures of RdRps and associated RNAs within nontranscribing and transcribing cypoviruses (NCPV and TCPV, respectively), using a combination of cryo-electron microscopy (cryo-EM) and a symmetry-mismatch reconstruction method. The RdRps and associated RNAs appear to exhibit a pseudo-D3 symmetric organization in both NCPV and TCPV. However, the molecular interactions between RdRps and the genomic RNA were found to differ in these states. Our work provides insight into the mechanisms of the replication and transcription in dsRNA viruses and paves a way for structural determination of lower-symmetry complexes enclosed in higher-symmetry structures.
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Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus.,Liu H, Cheng L Science. 2015 Sep 18;349(6254):1347-50. doi: 10.1126/science.aaa4938. PMID:26383954<ref>PMID:26383954</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3ja4" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Bombyx mori cypovirus 1]]
[[Category: Bombyx mori cypovirus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cheng, L]]
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[[Category: Cheng L]]
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[[Category: Liu, H]]
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[[Category: Liu H]]
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[[Category: Icosahedral virus]]
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[[Category: Rna-dependent rna polymerase]]
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[[Category: Transcribing cypoviruse]]
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[[Category: Transferase]]
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Current revision

RNA-dependent RNA polymerases of transcribing cypoviruses

3ja4, resolution 4.80Å

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OCA

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