3jd5

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Current revision (08:44, 7 February 2024) (edit) (undo)
 
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<SX load='3jd5' size='340' side='right' viewer='molstar' caption='[[3jd5]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
<SX load='3jd5' size='340' side='right' viewer='molstar' caption='[[3jd5]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3jd5]] is a 33 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3j6v 3j6v]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JD5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3jd5]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3j6v 3j6v]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JD5 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jd5 OCA], [https://pdbe.org/3jd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jd5 RCSB], [https://www.ebi.ac.uk/pdbsum/3jd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jd5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jd5 OCA], [https://pdbe.org/3jd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jd5 RCSB], [https://www.ebi.ac.uk/pdbsum/3jd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jd5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RT34_BOVIN RT34_BOVIN]] Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.[UniProtKB:Q9JIK9] [[https://www.uniprot.org/uniprot/PTCD3_BOVIN PTCD3_BOVIN]] Mitochondrial RNA-binding protein that has a role in mitochondrial translation. [[https://www.uniprot.org/uniprot/RT29_BOVIN RT29_BOVIN]] Involved in mediating interferon-gamma-induced cell death.
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[https://www.uniprot.org/uniprot/RT24_BOVIN RT24_BOVIN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The mammalian mitochondrial ribosomes (mitoribosomes) are responsible for synthesizing 13 membrane proteins that form essential components of the complexes involved in oxidative phosphorylation or ATP generation for the eukaryotic cell. The mammalian 55S mitoribosome contains significantly smaller rRNAs and a large mass of mitochondrial ribosomal proteins (MRPs), including large mito-specific amino acid extensions and insertions in MRPs that are homologous to bacterial ribosomal proteins and an additional 35 mito-specific MRPs. Here we present the cryo-EM structure analysis of the small (28S) subunit (SSU) of the 55S mitoribosome. We find that the mito-specific extensions in homologous MRPs generally are involved in inter-MRP contacts and in contacts with mito-specific MRPs, suggesting a stepwise evolution of the current architecture of the mitoribosome. Although most of the mito-specific MRPs and extensions of homologous MRPs are situated on the peripheral regions, they also contribute significantly to the formation of linings of the mRNA and tRNA paths, suggesting a tailor-made structural organization of the mito-SSU for the recruitment of mito-specific mRNAs, most of which do not possess a 5' leader sequence. In addition, docking of previously published coordinates of the large (39S) subunit (LSU) into the cryo-EM map of the 55S mitoribosome reveals that mito-specific MRPs of both the SSU and LSU are involved directly in the formation of six of the 15 intersubunit bridges.
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Cryo-EM structure of the small subunit of the mammalian mitochondrial ribosome.,Kaushal PS, Sharma MR, Booth TM, Haque EM, Tung CS, Sanbonmatsu KY, Spremulli LL, Agrawal RK Proc Natl Acad Sci U S A. 2014 May 20;111(20):7284-9. doi:, 10.1073/pnas.1401657111. Epub 2014 May 5. PMID:24799711<ref>PMID:24799711</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3jd5" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
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== References ==
 
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<references/>
 
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__TOC__
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Agrawal, R K]]
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[[Category: Agrawal RK]]
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[[Category: Booth, T M]]
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[[Category: Booth TM]]
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[[Category: Haque, E M]]
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[[Category: Haque EM]]
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[[Category: Kaushal, P S]]
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[[Category: Kaushal PS]]
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[[Category: Sanbonmatsu, K Y]]
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[[Category: Sanbonmatsu KY]]
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[[Category: Sharma, M R]]
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[[Category: Sharma MR]]
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[[Category: Spremulli, L L]]
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[[Category: Spremulli LL]]
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[[Category: Tung, C S]]
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[[Category: Tung CS]]
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[[Category: Mammalian 55s mitoribosome]]
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[[Category: Mitoribosome]]
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[[Category: Protein synthesis]]
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[[Category: Ribosome]]
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[[Category: Rna-protein complex]]
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Current revision

Cryo-EM structure of the small subunit of the mammalian mitochondrial ribosome

3jd5, resolution 7.00Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

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