3lle
From Proteopedia
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<StructureSection load='3lle' size='340' side='right'caption='[[3lle]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='3lle' size='340' side='right'caption='[[3lle]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[3lle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3lle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LLE FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SGE:13-METHYL-13,14-DIHYDRO[1,3]BENZODIOXOLO[5,6-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDINE'>SGE</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85Å</td></tr> |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SGE:13-METHYL-13,14-DIHYDRO[1,3]BENZODIOXOLO[5,6-C][1,3]DIOXOLO[4,5-I]PHENANTHRIDINE'>SGE</scene></td></tr> | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lle OCA], [https://pdbe.org/3lle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lle RCSB], [https://www.ebi.ac.uk/pdbsum/3lle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lle ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lle OCA], [https://pdbe.org/3lle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lle RCSB], [https://www.ebi.ac.uk/pdbsum/3lle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lle ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
- | + | [https://www.uniprot.org/uniprot/S100B_BOVIN S100B_BOVIN] Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (By similarity).<ref>PMID:14661952</ref> | |
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==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Bos taurus]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Charpentier | + | [[Category: Charpentier TH]] |
- | [[Category: Weber | + | [[Category: Weber DJ]] |
- | [[Category: Wilder | + | [[Category: Wilder PW]] |
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Revision as of 08:46, 7 February 2024
X-ray structure of bovine SC0322,Ca(2+)-S100B
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