5qhj

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Current revision (08:54, 7 February 2024) (edit) (undo)
 
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<StructureSection load='5qhj' size='340' side='right'caption='[[5qhj]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
<StructureSection load='5qhj' size='340' side='right'caption='[[5qhj]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5qhj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QHJ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5qhj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QHJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QHJ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOV:(2S)-1-{[(2H-1,3-benzodioxol-5-yl)methyl]amino}propan-2-ol'>GOV</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FAM83B, C6orf143 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOV:(2S)-1-{[(2H-1,3-benzodioxol-5-yl)methyl]amino}propan-2-ol'>GOV</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qhj OCA], [https://pdbe.org/5qhj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qhj RCSB], [https://www.ebi.ac.uk/pdbsum/5qhj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qhj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qhj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qhj OCA], [https://pdbe.org/5qhj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qhj RCSB], [https://www.ebi.ac.uk/pdbsum/5qhj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qhj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FA83B_HUMAN FA83B_HUMAN]] Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.<ref>PMID:22886302</ref> <ref>PMID:23676467</ref> <ref>PMID:23912460</ref>
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[https://www.uniprot.org/uniprot/FA83B_HUMAN FA83B_HUMAN] Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. May activate both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades.<ref>PMID:22886302</ref> <ref>PMID:23676467</ref> <ref>PMID:23912460</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Bufton, J C]]
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[[Category: Bufton JC]]
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[[Category: Bullock, A N]]
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[[Category: Bullock AN]]
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[[Category: Collins, P]]
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[[Category: Collins P]]
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[[Category: Delft, F von]]
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[[Category: Douangamath A]]
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[[Category: Douangamath, A]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Fox AE]]
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[[Category: Fox, A E]]
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[[Category: Krojer T]]
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[[Category: Krojer, T]]
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[[Category: Pinkas DM]]
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[[Category: Pinkas, D M]]
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[[Category: Talon R]]
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[[Category: Talon, R]]
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[[Category: Zhang R]]
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[[Category: Zhang, R]]
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[[Category: Von Delft F]]
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[[Category: Duf1669 domain]]
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[[Category: Pandda]]
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[[Category: Protein binding]]
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[[Category: Sgc - diamond i04-1 fragment screening]]
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[[Category: Xchemexplorer]]
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Current revision

PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of human FAM83B in complex with FMOPL000709a

PDB ID 5qhj

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OCA

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