5qiv

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<StructureSection load='5qiv' size='340' side='right'caption='[[5qiv]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
<StructureSection load='5qiv' size='340' side='right'caption='[[5qiv]], [[Resolution|resolution]] 1.39&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5qiv]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QIV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QIV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5qiv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QIV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J5P:N-acetyl-2-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]acetohydrazide'>J5P</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.39&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=J5P:N-acetyl-2-[(3R)-1,1-dioxo-1lambda~6~-thiolan-3-yl]acetohydrazide'>J5P</scene>, <scene name='pdbligand=UNL:UNKNOWN+LIGAND'>UNL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qiv OCA], [http://pdbe.org/5qiv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qiv RCSB], [http://www.ebi.ac.uk/pdbsum/5qiv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qiv ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qiv OCA], [https://pdbe.org/5qiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qiv RCSB], [https://www.ebi.ac.uk/pdbsum/5qiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qiv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OTUB2_HUMAN OTUB2_HUMAN]] Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12704427</ref> <ref>PMID:18954305</ref>
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[https://www.uniprot.org/uniprot/OTUB2_HUMAN OTUB2_HUMAN] Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.<ref>PMID:12704427</ref> <ref>PMID:18954305</ref>
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ubiquitinyl hydrolase 1]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Bradley AR]]
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[[Category: Bradley, A R]]
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[[Category: Brandao-Neto J]]
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[[Category: Brandao-Neto, J]]
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[[Category: Collins P]]
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[[Category: Collins, P]]
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[[Category: Douangamath A]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Douangamath, A]]
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[[Category: Krojer T]]
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[[Category: Edwards, A]]
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[[Category: London N]]
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[[Category: Krojer, T]]
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[[Category: Resnick E]]
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[[Category: London, N]]
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[[Category: Sethi R]]
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[[Category: Resnick, E]]
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[[Category: Talon R]]
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[[Category: Sethi, R]]
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[[Category: Von Delft F]]
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[[Category: Talon, R]]
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[[Category: Deubiquitinating enzyme otub2]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protease otub2]]
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[[Category: Sgc - diamond i04-1 fragment screening]]
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[[Category: Xchemexplorer]]
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Revision as of 08:56, 7 February 2024

Covalent fragment group deposition -- Crystal Structure of OUTB2 in complex with PCM-0102998

PDB ID 5qiv

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