1q4q

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[[Image:1q4q.gif|left|200px]]
[[Image:1q4q.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1q4q| PDB=1q4q | SCENE= }}
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|RELATEDENTRY=[[1jd4|1JD4]], [[1jd5|1JD5]], [[1jd6|1JD6]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q4q OCA], [http://www.ebi.ac.uk/pdbsum/1q4q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q4q RCSB]</span>
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'''Crystal structure of a DIAP1-Dronc complex'''
'''Crystal structure of a DIAP1-Dronc complex'''
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[[Category: Shi, Y.]]
[[Category: Shi, Y.]]
[[Category: Yan, N.]]
[[Category: Yan, N.]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: caspase]]
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[[Category: Caspase]]
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[[Category: iap]]
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[[Category: Iap]]
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[[Category: mechanism]]
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[[Category: Mechanism]]
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[[Category: ubiquitination]]
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[[Category: Ubiquitination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:51:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:08:48 2008''
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Revision as of 02:51, 3 May 2008

Image:1q4q.gif

Template:STRUCTURE 1q4q

Crystal structure of a DIAP1-Dronc complex


Overview

The inhibitor of apoptosis protein DIAP1 inhibits Dronc-dependent cell death by ubiquitinating Dronc. The pro-death proteins Reaper, Hid and Grim (RHG) promote apoptosis by antagonizing DIAP1 function. Here we report the structural basis of Dronc recognition by DIAP1 as well as a novel mechanism by which the RHG proteins remove DIAP1-mediated downregulation of Dronc. Biochemical and structural analyses revealed that the second BIR (BIR2) domain of DIAP1 recognizes a 12-residue sequence in Dronc. This recognition is essential for DIAP1 binding to Dronc, and for targeting Dronc for ubiquitination. Notably, the Dronc-binding surface on BIR2 coincides with that required for binding to the N termini of the RHG proteins, which competitively eliminate DIAP1-mediated ubiquitination of Dronc. These observations reveal the molecular mechanisms of how DIAP1 recognizes Dronc, and more importantly, how the RHG proteins remove DIAP1-mediated ubiquitination of Dronc.

About this Structure

1Q4Q is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination., Chai J, Yan N, Huh JR, Wu JW, Li W, Hay BA, Shi Y, Nat Struct Biol. 2003 Nov;10(11):892-8. Epub 2003 Sep 28. PMID:14517550 Page seeded by OCA on Sat May 3 05:51:50 2008

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