8iaj

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'''Unreleased structure'''
 
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The entry 8iaj is ON HOLD until 2025-02-08
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==Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3A) complex==
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<StructureSection load='8iaj' size='340' side='right'caption='[[8iaj]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8iaj]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana], [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IAJ FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=Z1T:N-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]tetracosanamide'>Z1T</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8iaj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8iaj OCA], [https://pdbe.org/8iaj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8iaj RCSB], [https://www.ebi.ac.uk/pdbsum/8iaj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8iaj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LCB1_YEAST LCB1_YEAST] Component of serine palmitoyltransferase (SPT), which catalyzes the committed step in the synthesis of sphingolipids, the condensation of serine with palmitoyl CoA to form the long chain base 3-ketosphinganine.<ref>PMID:11781309</ref> <ref>PMID:8058731</ref> [https://www.uniprot.org/uniprot/LCB1_ARATH LCB1_ARATH] Serine palmitoyltransferase (SPT). The heterodimer formed with LCB2 constitutes the catalytic core. Involved in the regulation of the programmed cell death (PCD) signaling pathway. Plays an important role during male gametogenesis and embryogenesis.<ref>PMID:17194770</ref> <ref>PMID:18059378</ref> <ref>PMID:18218968</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arabidopsis thaliana]]
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Gong X]]
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[[Category: Xie T]]

Revision as of 07:19, 14 February 2024

Cryo-EM structure of the yeast SPT-ORM2 (ORM2-S3A) complex

PDB ID 8iaj

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