8q5h
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Human KMN network (outer kinetochore)== | |
| - | + | <StructureSection load='8q5h' size='340' side='right'caption='[[8q5h]], [[Resolution|resolution]] 4.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8q5h]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q5H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q5H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q5h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q5h OCA], [https://pdbe.org/8q5h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q5h RCSB], [https://www.ebi.ac.uk/pdbsum/8q5h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q5h ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SPC24_HUMAN SPC24_HUMAN] Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020).<ref>PMID:14738735</ref> <ref>PMID:23085020</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Musacchio A]] | ||
| + | [[Category: Polley S]] | ||
| + | [[Category: Raisch T]] | ||
| + | [[Category: Raunser S]] | ||
| + | [[Category: Vetter I]] | ||
Revision as of 07:20, 14 February 2024
Human KMN network (outer kinetochore)
| |||||||||||
