8qn0

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Current revision (07:20, 14 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8qn0 is ON HOLD until Paper Publication
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==Soluble epoxide hydrolase in complex with RK3==
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<StructureSection load='8qn0' size='340' side='right'caption='[[8qn0]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
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Authors: Kumar, A., Zhu, F., Ehrler, J.M.H., Li, F., Empel, C., Xu, Y., Atodiresei, I., Koenigs, R.M., Proschak, E., Knapp, S., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8qn0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QN0 FirstGlance]. <br>
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Description: Soluble epoxide hydrolase in complex with RK3
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=WJ5:(3~{a}~{R},6~{a}~{S})-~{N}-[(2,4-dichlorophenyl)methyl]-5-(4-methylphenyl)sulfonyl-1,3,3~{a},4,6,6~{a}-hexahydropyrrolo[3,4-c]pyrrole-2-carboxamide'>WJ5</scene></td></tr>
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[[Category: Proschak, E]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qn0 OCA], [https://pdbe.org/8qn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qn0 RCSB], [https://www.ebi.ac.uk/pdbsum/8qn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qn0 ProSAT]</span></td></tr>
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[[Category: Xu, Y]]
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</table>
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[[Category: Ehrler, J.M.H]]
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== Function ==
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[[Category: Knapp, S]]
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[https://www.uniprot.org/uniprot/HYES_HUMAN HYES_HUMAN] Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid, 12-phosphonooxy-octadec-9E-enoic acid, and p-nitrophenyl phospate.<ref>PMID:12574508</ref> <ref>PMID:12574510</ref>
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[[Category: Koenigs, R.M]]
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== References ==
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[[Category: Li, F]]
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<references/>
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[[Category: Kumar, A]]
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__TOC__
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[[Category: Empel, C]]
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</StructureSection>
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Homo sapiens]]
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[[Category: Zhu, F]]
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[[Category: Large Structures]]
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[[Category: Atodiresei, I]]
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[[Category: Atodiresei I]]
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[[Category: Ehrler JMH]]
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[[Category: Empel C]]
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[[Category: Knapp S]]
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[[Category: Koenigs RM]]
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[[Category: Kumar A]]
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[[Category: Li F]]
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[[Category: Proschak E]]
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[[Category: Xu Y]]
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[[Category: Zhu F]]

Current revision

Soluble epoxide hydrolase in complex with RK3

PDB ID 8qn0

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