8rq4

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m (Protected "8rq4" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8rq4 is ON HOLD
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==Cryo-em structure of the rat Multidrug resistance-associated protein 2 (rMrp2) in complex with probenecid==
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<StructureSection load='8rq4' size='340' side='right'caption='[[8rq4]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
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Authors: Mazza, T., Beis, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8rq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8RQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8RQ4 FirstGlance]. <br>
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Description: Cryo-em structure of the rat Multidrug resistance-associated protein 2 (rMrp2) in complex with probenecid
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.45&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RTO:4-(dipropylsulfamoyl)benzoic+acid'>RTO</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
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[[Category: Mazza, T]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8rq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8rq4 OCA], [https://pdbe.org/8rq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8rq4 RCSB], [https://www.ebi.ac.uk/pdbsum/8rq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8rq4 ProSAT]</span></td></tr>
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[[Category: Beis, K]]
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MRP2_RAT MRP2_RAT] Defects in Abcc2 are a cause of hereditary conjugated hyperbilirubinemia (EHBR).<ref>PMID:8599091</ref> [REFERENCE:3]
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== Function ==
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[https://www.uniprot.org/uniprot/MRP2_RAT MRP2_RAT] ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates (PubMed:8662992, PubMed:10421658, PubMed:10220572, PubMed:11248200). Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification (PubMed:10421658). Mediates also hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4 (PubMed:10220572, PubMed:8662992). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:11248200). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (By similarity).[UniProtKB:Q92887]<ref>PMID:10220572</ref> <ref>PMID:10421658</ref> <ref>PMID:11248200</ref> <ref>PMID:8662992</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Rattus norvegicus]]
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[[Category: Beis K]]
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[[Category: Mazza T]]

Revision as of 07:21, 14 February 2024

Cryo-em structure of the rat Multidrug resistance-associated protein 2 (rMrp2) in complex with probenecid

PDB ID 8rq4

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