8vts
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Meis1 homeobox domain bound to paromomycin fragment== | |
| - | + | <StructureSection load='8vts' size='340' side='right'caption='[[8vts]], [[Resolution|resolution]] 1.91Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8vts]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8VTS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8VTS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=RIO:RIBOSTAMYCIN'>RIO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8vts FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8vts OCA], [https://pdbe.org/8vts PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8vts RCSB], [https://www.ebi.ac.uk/pdbsum/8vts PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8vts ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/MEIS1_MOUSE MEIS1_MOUSE] Meis1 serves as a site of viral integration in 15% of the tumors arising in BXH-2 mice that develop myeloid leukemia as a result of the expression of an ecotropic murine leukemia virus.<ref>PMID:7565694</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MEIS1_MOUSE MEIS1_MOUSE] Acts as a transcriptional regulator of PAX6. Also acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.<ref>PMID:12183364</ref> <ref>PMID:15882575</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Ahmed MS]] | ||
| + | [[Category: Nguyen NUN]] | ||
| + | [[Category: Tomchick DR]] | ||
Revision as of 07:23, 14 February 2024
Meis1 homeobox domain bound to paromomycin fragment
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