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1q6k

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[[Image:1q6k.jpg|left|200px]]
[[Image:1q6k.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1q6k |SIZE=350|CAPTION= <scene name='initialview01'>1q6k</scene>, resolution 2.1&Aring;
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The line below this paragraph, containing "STRUCTURE_1q6k", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TCO:TERT-BUTYL(1S)-1-CYCLOHEXYL-2-OXOETHYLCARBAMATE'>TCO</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_K Cathepsin K], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.38 3.4.22.38] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CTSK OR CTSO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1q6k| PDB=1q6k | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q6k OCA], [http://www.ebi.ac.uk/pdbsum/1q6k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q6k RCSB]</span>
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}}
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'''Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate'''
'''Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate'''
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[[Category: Willard, D H.]]
[[Category: Willard, D H.]]
[[Category: Wright, L L.]]
[[Category: Wright, L L.]]
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[[Category: cathepsin k]]
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[[Category: Cathepsin k]]
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[[Category: catk]]
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[[Category: Catk]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:55:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:09:31 2008''
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Revision as of 02:55, 3 May 2008

Image:1q6k.jpg

Template:STRUCTURE 1q6k

Cathepsin K complexed with t-butyl(1S)-1-cyclohexyl-2-oxoethylcarbamate


Overview

The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.

About this Structure

1Q6K is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Exploration of the P1 SAR of aldehyde cathepsin K inhibitors., Catalano JG, Deaton DN, Furfine ES, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Willard DH Jr, Wright LL, Bioorg Med Chem Lett. 2004 Jan 5;14(1):275-8. PMID:14684342 Page seeded by OCA on Sat May 3 05:55:35 2008

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OCA

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