1mjf
From Proteopedia
(Difference between revisions)
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<StructureSection load='1mjf' size='340' side='right'caption='[[1mjf]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='1mjf' size='340' side='right'caption='[[1mjf]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1mjf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1mjf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MJF FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.798Å</td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mjf OCA], [https://pdbe.org/1mjf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mjf RCSB], [https://www.ebi.ac.uk/pdbsum/1mjf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mjf ProSAT], [https://www.topsan.org/Proteins/SECSG/1mjf TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mjf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mjf OCA], [https://pdbe.org/1mjf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mjf RCSB], [https://www.ebi.ac.uk/pdbsum/1mjf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mjf ProSAT], [https://www.topsan.org/Proteins/SECSG/1mjf TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/SPEE_PYRFU SPEE_PYRFU] Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to various amine acceptors such as cadaverine, putrescine, agmatine, 1,3-diaminopropane, and sym-nor-spermidine. The reaction involves a nucleophilic attack on the C-3 methylene of the propylamine moiety adjacent to the positively charged sulfur of decarboxy-AdoMet.<ref>PMID:17545282</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Atcc 43587]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Spermidine synthase]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: PSI, Protein structure initiative]] | ||
[[Category: Pyrococcus furiosus]] | [[Category: Pyrococcus furiosus]] | ||
| - | [[Category: Secsg]] | ||
| - | [[Category: Spermidine synthetase]] | ||
| - | [[Category: Transferase]] | ||
Current revision
PUTATIVE SPERMIDINE SYNTHETASE FROM PYROCOCCUS FURIOSUS PFU-132382
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