1n0n
From Proteopedia
(Difference between revisions)
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<StructureSection load='1n0n' size='340' side='right'caption='[[1n0n]], [[Resolution|resolution]] 1.82Å' scene=''> | <StructureSection load='1n0n' size='340' side='right'caption='[[1n0n]], [[Resolution|resolution]] 1.82Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1n0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1n0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1lus 1lus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N0N FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n0n OCA], [https://pdbe.org/1n0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n0n RCSB], [https://www.ebi.ac.uk/pdbsum/1n0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n0n ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n0n OCA], [https://pdbe.org/1n0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n0n RCSB], [https://www.ebi.ac.uk/pdbsum/1n0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n0n ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/SODM_HUMAN SODM_HUMAN] Genetic variation in SOD2 is associated with susceptibility to microvascular complications of diabetes type 6 (MVCD6) [MIM:[https://omim.org/entry/612634 612634]. These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/SODM_HUMAN SODM_HUMAN] Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.<ref>PMID:10334867</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Beyer Jr WF]] | |
| - | [[Category: Beyer | + | [[Category: Borgstahl GEO]] |
| - | [[Category: Borgstahl | + | [[Category: Hallewell RA]] |
| - | [[Category: Hallewell | + | [[Category: Hickey MJ]] |
| - | [[Category: Hickey | + | [[Category: Parge HE]] |
| - | [[Category: Parge | + | [[Category: Tainer JA]] |
| - | [[Category: Tainer | + | |
| - | + | ||
| - | + | ||
Current revision
Catalytic and Structural Effects of Amino-Acid Substitution at His30 in Human Manganese Superoxide Dismutase
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