1pe8

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Current revision (08:07, 14 February 2024) (edit) (undo)
 
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<StructureSection load='1pe8' size='340' side='right'caption='[[1pe8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='1pe8' size='340' side='right'caption='[[1pe8]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1pe8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/'bacillus_thermoproteolyticus' 'bacillus thermoproteolyticus']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PE8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1pe8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_thermoproteolyticus Bacillus thermoproteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PE8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR5:2-ETHOXYETHYLPHOSPHINATE'>BR5</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=LEN:3-METHYLBUTAN-1-AMINE'>LEN</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1pe5|1pe5]], [[1pe7|1pe7]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR5:2-ETHOXYETHYLPHOSPHINATE'>BR5</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=LEN:3-METHYLBUTAN-1-AMINE'>LEN</scene>, <scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thermolysin Thermolysin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.27 3.4.24.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pe8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pe8 OCA], [https://pdbe.org/1pe8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pe8 RCSB], [https://www.ebi.ac.uk/pdbsum/1pe8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pe8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pe8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pe8 OCA], [https://pdbe.org/1pe8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pe8 RCSB], [https://www.ebi.ac.uk/pdbsum/1pe8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pe8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/THER_BACTH THER_BACTH]] Extracellular zinc metalloprotease.
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[https://www.uniprot.org/uniprot/THER_BACTH THER_BACTH] Extracellular zinc metalloprotease.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Bacillus thermoproteolyticus]]
[[Category: Bacillus thermoproteolyticus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thermolysin]]
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[[Category: Bartlett PA]]
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[[Category: Bartlett, P A]]
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[[Category: Juers D]]
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[[Category: Juers, D]]
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[[Category: Matthews BW]]
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[[Category: Matthews, B W]]
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[[Category: Pyun H-J]]
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[[Category: Pyun, H J]]
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[[Category: Hydrolase]]
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[[Category: Metalloprotease]]
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Current revision

Thermolysin with monocyclic inhibitor

PDB ID 1pe8

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