1qva

<table><tr><td colspan='2'>[[1qva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QVA FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qva OCA], [https://pdbe.org/1qva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qva RCSB], [https://www.ebi.ac.uk/pdbsum/1qva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qva ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

The eukaryotic translation initiation factor 4A (elF4A) is a representative of the DEAD-box RNA helicase protein family. We have solved the crystallographic structure of the amino-terminal domain (residues 1-223) of yeast elF4A. The domain is built around a core scaffold, a parallel alpha-beta motif with five beta strands, that is found in other RNA and DNA helicases, as well as in the RecA protein. The amino acid sequence motifs that are conserved within the helicase family are localized to the beta strand--&gt;alpha helix junctions within the core. The core of the amino terminal domain of elF4A is amplified with additional structural elements that differ from those of other helicases. The phosphate binding loop (the Walker A motif) is in an unusual closed conformation. The crystallographic structure reveals specific interactions between amino acid residues of the phosphate binding loop, the DEAD motif, and the SAT motif, whose alteration is known to impair coupling between the ATPase cycle and the RNA unwinding activity of elF4A.

Crystallographic structure of the amino terminal domain of yeast initiation factor 4A, a representative DEAD-box RNA helicase.,Johnson ER, McKay DB RNA. 1999 Dec;5(12):1526-34. PMID:10606264<ref>PMID:10606264</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Atcc 18824]]

[[Category: Johnson, E R]]

[[Category: McKay, D B]]

[[Category: Dead box]]

[[Category: Rna helicase]]