1sac

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(New page: 200px<br /> <applet load="1sac" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sac, resolution 2.0&Aring;" /> '''THE STRUCTURE OF PEN...)
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Revision as of 17:05, 12 November 2007

Image:1sac.gif

1sac, resolution 2.0Å

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THE STRUCTURE OF PENTAMERIC HUMAN SERUM AMYLOID P COMPONENT

Contents

Overview

The three-dimensional structure of pentameric human serum amyloid P, component at high resolution, the first reported for a pentraxin, reveals, that the tertiary fold is remarkably similar to that of the legume, lectins. Carboxylate and phosphate compounds bind directly to two calcium, ions; interactions with a carboxyethylidene ring are mediated by Asn 59, and Gln 148 ligands of the calcium ions. These X-ray results indicate the, probable modes of binding of the biologically important ligands, DNA and, amyloid fibrils.

Disease

Known disease associated with this structure: Amyloidosis, secondary, susceptibility to OMIM:[104770]

About this Structure

1SAC is a Single protein structure of sequence from Homo sapiens with CA and ACY as ligands. Full crystallographic information is available from OCA.

Reference

Structure of pentameric human serum amyloid P component., Emsley J, White HE, O'Hara BP, Oliva G, Srinivasan N, Tickle IJ, Blundell TL, Pepys MB, Wood SP, Nature. 1994 Jan 27;367(6461):338-45. PMID:8114934

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