1s7m

<table><tr><td colspan='2'>[[1s7m]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1S7M FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hia ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1s7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7m OCA], [http://pdbe.org/1s7m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s7m RCSB], [http://www.ebi.ac.uk/pdbsum/1s7m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s7m ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Haemophilus influenzae is an important human pathogen that initiates infection by colonizing the upper respiratory tract. The H. influenzae Hia autotransporter is an adhesive protein that promotes adherence to respiratory epithelial cells. Hia adhesive activity resides in two homologous binding domains, called HiaBD1 and HiaBD2. These domains interact with the same host cell receptor, but bind with different affinities. In this report, we describe the crystal structure of the high-affinity HiaBD1 binding domain, which has a novel trimeric architecture with three-fold symmetry and a mushroom shape. The subunit constituents of the trimer are extensively intertwined. The receptor-binding pocket is formed by an acidic patch that is present on all three faces of the trimer, providing potential for a multivalent interaction with the host cell surface, analogous to observations with the trimeric tumor necrosis factor superfamily of proteins. Hia is a novel example of a bacterial trimeric adhesin and may be the prototype member of a large family of bacterial virulence proteins with a similar architecture.

Structural basis for host recognition by the Haemophilus influenzae Hia autotransporter.,Yeo HJ, Cotter SE, Laarmann S, Juehne T, St Geme JW 3rd, Waksman G EMBO J. 2004 Mar 24;23(6):1245-56. Epub 2004 Mar 18. PMID:15029242<ref>PMID:15029242</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Bacterium influenzae lehmann and neumann 1896]]

[[Category: Cotter, S E]]

[[Category: Geme, J W.St]]

[[Category: Juehne, T]]

[[Category: Laarmann, S]]

[[Category: Waksman, G]]

[[Category: Yeo, H J]]

[[Category: Adhesion]]

[[Category: Homotrimer]]