1s7o

<table><tr><td colspan='2'>[[1s7o]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_(serotype_m3) Streptococcus pyogenes (serotype m3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S7O OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1S7O FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPY1201, SPYM3_0842, SPS1042, SPYM18_1152 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=301448 Streptococcus pyogenes (serotype M3)])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1s7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s7o OCA], [http://pdbe.org/1s7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s7o RCSB], [http://www.ebi.ac.uk/pdbsum/1s7o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s7o ProSAT], [http://www.topsan.org/Proteins/BSGC/1s7o TOPSAN]</span></td></tr>

[[http://www.uniprot.org/uniprot/Y1201_STRP1 Y1201_STRP1]] Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein (By similarity).

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== Publication Abstract from PubMed ==

The crystal structure of the putative DNA-binding protein SP_1288 (gi/15675166, also listed as gi/28895954) from Streptococcus pyogenes has been determined by X-ray crystallography to a resolution of 2.3 A using anomalous diffraction data at the Se peak wavelength. SP_1288 belongs to a family of proteins whose cellular function is associated with the signal recognition particle; no structural information has been available until now about the members of the family. Crystallographic analysis revealed that the overall fold of SP_1288 consists exclusively of alpha-helices and that 75% of the structure has good similarity to domain 4 of the sigma subunit of RNA polymerase. This suggests its possible involvement in the biochemical function of transcription initiation, which includes interaction with DNA.

Structure of the putative DNA-binding protein SP_1288 from Streptococcus pyogenes.,Oganesyan V, Pufan R, DeGiovanni A, Yokota H, Kim R, Kim SH Acta Crystallogr D Biol Crystallogr. 2004 Jul;60(Pt 7):1266-71. Epub 2004, Jun 22. PMID:15213388<ref>PMID:15213388</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1s7o" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Structural genomic]]

[[Category: DeGiovanni, A]]

[[Category: Kim, R]]

[[Category: Kim, S H]]

[[Category: Oganesyan, V]]

[[Category: Pufan, R]]

[[Category: Yokota, H]]

[[Category: X-rat crystallography]]