1q9c

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[[Image:1q9c.gif|left|200px]]
[[Image:1q9c.gif|left|200px]]
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{{Structure
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|GENE= SOS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_1q9c| PDB=1q9c | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1q9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1q9c OCA], [http://www.ebi.ac.uk/pdbsum/1q9c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1q9c RCSB]</span>
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'''Crystal Structure of the Histone domain of Son of Sevenless'''
'''Crystal Structure of the Histone domain of Son of Sevenless'''
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[[Category: Soisson, S M.]]
[[Category: Soisson, S M.]]
[[Category: Sondermann, H.]]
[[Category: Sondermann, H.]]
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[[Category: h2a]]
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[[Category: H2a]]
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[[Category: h2b]]
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[[Category: H2b]]
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[[Category: histone fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:01:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:10:36 2008''
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Revision as of 03:01, 3 May 2008

Image:1q9c.gif

Template:STRUCTURE 1q9c

Crystal Structure of the Histone domain of Son of Sevenless


Contents

Overview

The Ras activator Son of Sevenless (Sos) contains a Cdc25 homology domain, responsible for nucleotide exchange, as well as Dbl/Pleckstrin homology (DH/PH) domains. We have determined the crystal structure of the N-terminal segment of human Sos1 (residues 1-191) and show that it contains two tandem histone folds. While the N-terminal domain is monomeric in solution, its structure is surprisingly similar to that of histone dimers, with both subunits of the histone "dimer" being part of the same peptide chain. One histone fold corresponds to the region of Sos that is clearly similar in sequence to histones (residues 91-191), whereas the other is formed by residues in Sos (1-90) that are unrelated in sequence to histones. Residues that form a contiguous patch on the surface of the histone domain of Sos are conserved from C. elegans to humans, suggesting a potential role for this domain in protein-protein interactions.

Disease

Known disease associated with this structure: Fibromatosis, gingival OMIM:[182530], Noonan syndrome 4 OMIM:[182530]

About this Structure

1Q9C is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless., Sondermann H, Soisson SM, Bar-Sagi D, Kuriyan J, Structure. 2003 Dec;11(12):1583-93. PMID:14656442 Page seeded by OCA on Sat May 3 06:01:50 2008

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