1x6i

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Current revision (08:48, 14 February 2024) (edit) (undo)
 
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<StructureSection load='1x6i' size='340' side='right'caption='[[1x6i]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='1x6i' size='340' side='right'caption='[[1x6i]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1x6i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X6I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1x6i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X6I FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1x6j|1x6j]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ygfY ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x6i OCA], [https://pdbe.org/1x6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x6i RCSB], [https://www.ebi.ac.uk/pdbsum/1x6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x6i ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x6i OCA], [https://pdbe.org/1x6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x6i RCSB], [https://www.ebi.ac.uk/pdbsum/1x6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x6i ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CPTB_ECOLI CPTB_ECOLI]] Antitoxin component of a toxin-antitoxin (TA) module. When coexpressed with cognate toxin CptA, the antitoxin neutralizes CptA's toxicity. Has been suggested to be a transcriptional regulator.<ref>PMID:22239607</ref>
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[https://www.uniprot.org/uniprot/SDHE_ECOLI SDHE_ECOLI] An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins (PubMed:22474332, PubMed:26644464, PubMed:24374335). Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH (PubMed:24374335, PubMed:26644464, PubMed:22474332). Required for flavinylation of the flavoprotein subunit FdrA of fumarate reductase (FDR) (PubMed:26644464). Binds 2 different sites on the flavoprotein target FrdA (and presumably also SdhA), possibly positioning FAD and protein to facilitate the covalent bond formation; covalent attachment of FAD is not required for SDH or FDR complex enzyme formation (PubMed:26644464). Overexpression of this protein and YgfX (formerly cptA) restores production of prodigiosin antibiotic (Pig) in Serratia strains with deletions of sdhE-ygfX (PubMed:22474332).<ref>PMID:23657679</ref> <ref>PMID:24374335</ref> <ref>PMID:26644464</ref> <ref>PMID:22474332</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Demirkan, E Sarikaya]]
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[[Category: Doseeva V]]
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[[Category: Doseeva, V]]
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[[Category: Galkin A]]
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[[Category: Galkin, A]]
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[[Category: Herzberg O]]
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[[Category: Herzberg, O]]
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[[Category: Howard A]]
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[[Category: Howard, A]]
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[[Category: Krajewski W]]
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[[Category: Krajewski, W]]
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[[Category: Lim K]]
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[[Category: Lim, K]]
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[[Category: Pullalarevu S]]
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[[Category: Pullalarevu, S]]
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[[Category: Sarikaya Demirkan E]]
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[[Category: S2F, Structure 2.Function Project]]
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[[Category: Hypothetical protein]]
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[[Category: S2f]]
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[[Category: Structural genomic]]
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[[Category: Structure 2 function project]]
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[[Category: Transcriptional regulation]]
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[[Category: Unknown function]]
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[[Category: Ygfy]]
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Current revision

Crystal structure of ygfY from Escherichia coli

PDB ID 1x6i

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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