1yb1

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Current revision (08:56, 14 February 2024) (edit) (undo)
 
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<StructureSection load='1yb1' size='340' side='right'caption='[[1yb1]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
<StructureSection load='1yb1' size='340' side='right'caption='[[1yb1]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1yb1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YB1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1YB1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1yb1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YB1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AOI:ANDROSTERONE'>AOI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DHRS8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AOI:ANDROSTERONE'>AOI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/17-beta-estradiol_17-dehydrogenase 17-beta-estradiol 17-dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.62 1.1.1.62] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yb1 OCA], [https://pdbe.org/1yb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yb1 RCSB], [https://www.ebi.ac.uk/pdbsum/1yb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yb1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1yb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yb1 OCA], [http://pdbe.org/1yb1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1yb1 RCSB], [http://www.ebi.ac.uk/pdbsum/1yb1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1yb1 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DHB11_HUMAN DHB11_HUMAN]] Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
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[https://www.uniprot.org/uniprot/DHB11_HUMAN DHB11_HUMAN] Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 17-beta-estradiol 17-dehydrogenase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Arrowsmith C]]
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[[Category: Bray, J]]
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[[Category: Bray J]]
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[[Category: Bunkoczi, G]]
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[[Category: Bunkoczi G]]
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[[Category: Delft, F von]]
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[[Category: Edwards A]]
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[[Category: Edwards, A]]
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[[Category: Kavanagh K]]
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[[Category: Kavanagh, K]]
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[[Category: Lukacik P]]
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[[Category: Lukacik, P]]
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[[Category: Ng S]]
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[[Category: Ng, S]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U]]
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[[Category: Sundstrom M]]
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[[Category: Structural genomic]]
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[[Category: Von Delft F]]
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[[Category: Sundstrom, M]]
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[[Category: Hydroxysteroid dehydrogenase]]
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[[Category: Oxidoreductase]]
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[[Category: Sgc]]
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[[Category: Short chain dehydrogenase]]
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Current revision

Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI

PDB ID 1yb1

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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