1z58

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Current revision (09:02, 14 February 2024) (edit) (undo)
 
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z58 OCA], [https://pdbe.org/1z58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z58 RCSB], [https://www.ebi.ac.uk/pdbsum/1z58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z58 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z58 OCA], [https://pdbe.org/1z58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z58 RCSB], [https://www.ebi.ac.uk/pdbsum/1z58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z58 ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
 
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== Publication Abstract from PubMed ==
 
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RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins.
 
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A crevice adjoining the ribosome tunnel: hints for cotranslational folding.,Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23. PMID:15943964<ref>PMID:15943964</ref>
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==See Also==
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1z58" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
</StructureSection>

Current revision

Crystal structure of a complex of the ribosome large subunit with rapamycin

PDB ID 1z58

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