2b37

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Current revision (09:15, 14 February 2024) (edit) (undo)
 
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<StructureSection load='2b37' size='340' side='right'caption='[[2b37]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2b37' size='340' side='right'caption='[[2b37]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2b37]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B37 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2b37]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B37 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8PS:5-OCTYL-2-PHENOXYPHENOL'>8PS</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bvr|1bvr]], [[1enz|1enz]], [[1eny|1eny]], [[1zid|1zid]], [[1p44|1p44]], [[1p45|1p45]], [[2b36|2b36]], [[2b35|2b35]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8PS:5-OCTYL-2-PHENOXYPHENOL'>8PS</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">inhA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b37 OCA], [https://pdbe.org/2b37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b37 RCSB], [https://www.ebi.ac.uk/pdbsum/2b37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b37 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b37 OCA], [https://pdbe.org/2b37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b37 RCSB], [https://www.ebi.ac.uk/pdbsum/2b37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b37 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Amin, A]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Boyne, M S]]
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[[Category: Amin A]]
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[[Category: Johnson, F]]
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[[Category: Boyne MS]]
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[[Category: Kaur, T]]
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[[Category: Johnson F]]
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[[Category: Novichenok, P]]
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[[Category: Kaur T]]
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[[Category: Stratton, C]]
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[[Category: Novichenok P]]
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[[Category: Sullivan, T J]]
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[[Category: Stratton C]]
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[[Category: Truglio, J J]]
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[[Category: Sullivan TJ]]
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[[Category: Zhang, X]]
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[[Category: Truglio JJ]]
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[[Category: Enoyl reductase]]
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[[Category: Zhang X]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by 5-octyl-2-phenoxyphenol

PDB ID 2b37

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