2gcs
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gcs OCA], [https://pdbe.org/2gcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gcs RCSB], [https://www.ebi.ac.uk/pdbsum/2gcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gcs ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gcs OCA], [https://pdbe.org/2gcs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gcs RCSB], [https://www.ebi.ac.uk/pdbsum/2gcs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gcs ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis. | ||
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| - | Structural basis of glmS ribozyme activation by glucosamine-6-phosphate.,Klein DJ, Ferre-D'Amare AR Science. 2006 Sep 22;313(5794):1752-6. PMID:16990543<ref>PMID:16990543</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2gcs" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Ribozyme 3D structures|Ribozyme 3D structures]] | *[[Ribozyme 3D structures|Ribozyme 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme
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