1qbj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1qbj.jpg|left|200px]]
[[Image:1qbj.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1qbj |SIZE=350|CAPTION= <scene name='initialview01'>1qbj</scene>, resolution 2.1&Aring;
+
The line below this paragraph, containing "STRUCTURE_1qbj", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1qbj| PDB=1qbj | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qbj OCA], [http://www.ebi.ac.uk/pdbsum/1qbj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qbj RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX'''
'''CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX'''
Line 28: Line 25:
[[Category: Rould, M A.]]
[[Category: Rould, M A.]]
[[Category: Schwartz, T.]]
[[Category: Schwartz, T.]]
-
[[Category: protein/z-dna complex]]
+
[[Category: Protein/z-dna complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:06:05 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:11:29 2008''
+

Revision as of 03:06, 3 May 2008

Image:1qbj.jpg

Template:STRUCTURE 1qbj

CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX


Overview

The editing enzyme double-stranded RNA adenosine deaminase includes a DNA binding domain, Zalpha, which is specific for left-handed Z-DNA. The 2.1 angstrom crystal structure of Zalpha complexed to DNA reveals that the substrate is in the left-handed Z conformation. The contacts between Zalpha and Z-DNA are made primarily with the "zigzag" sugar-phosphate backbone, which provides a basis for the specificity for the Z conformation. A single base contact is observed to guanine in the syn conformation, characteristic of Z-DNA. Intriguingly, the helix-turn-helix motif, frequently used to recognize B-DNA, is used by Zalpha to contact Z-DNA.

About this Structure

1QBJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA., Schwartz T, Rould MA, Lowenhaupt K, Herbert A, Rich A, Science. 1999 Jun 11;284(5421):1841-5. PMID:10364558 Page seeded by OCA on Sat May 3 06:06:05 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qbj"
Personal tools