8d1m
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8d1m]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D1M FirstGlance]. <br> | <table><tr><td colspan='2'>[[8d1m]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8D1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8D1M FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d1m OCA], [https://pdbe.org/8d1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d1m RCSB], [https://www.ebi.ac.uk/pdbsum/8d1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d1m ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.11Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8d1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8d1m OCA], [https://pdbe.org/8d1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8d1m RCSB], [https://www.ebi.ac.uk/pdbsum/8d1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8d1m ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/BEST1_HUMAN BEST1_HUMAN] Nanophthalmos;Adult-onset foveomacular vitelliform dystrophy;Best vitelliform macular dystrophy;MRCS syndrome;Autosomal recessive bestrophinopathy;Autosomal dominant vitreoretinochoroidopathy;Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/BEST1_HUMAN BEST1_HUMAN] Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.<ref>PMID:11904445</ref> <ref>PMID:12907679</ref> <ref>PMID:18400985</ref> | |
==See Also== | ==See Also== | ||
Current revision
hBest1 Ca2+-unbound closed state
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