3msv

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Current revision (09:58, 14 February 2024) (edit) (undo)
 
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<StructureSection load='3msv' size='340' side='right'caption='[[3msv]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
<StructureSection load='3msv' size='340' side='right'caption='[[3msv]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3msv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MSV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3msv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MSV FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPCC4B3.07 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3msv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3msv OCA], [https://pdbe.org/3msv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3msv RCSB], [https://www.ebi.ac.uk/pdbsum/3msv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3msv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3msv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3msv OCA], [https://pdbe.org/3msv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3msv RCSB], [https://www.ebi.ac.uk/pdbsum/3msv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3msv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ETT1_SCHPO ETT1_SCHPO]] Required for correct translation termination (By similarity). Positive regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Acts also as a direct inhibitor of ofd1. Functions probably by inhibiting the ability of the ofd1 to accelerate Sre1N degradation in absence of oxygen.<ref>PMID:15116432</ref> <ref>PMID:19158663</ref>
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[https://www.uniprot.org/uniprot/ETT1_SCHPO ETT1_SCHPO] Required for correct translation termination (By similarity). Positive regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Acts also as a direct inhibitor of ofd1. Functions probably by inhibiting the ability of the ofd1 to accelerate Sre1N degradation in absence of oxygen.<ref>PMID:15116432</ref> <ref>PMID:19158663</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Fission yeast protein Sre1, the homolog of the mammalian sterol regulatory element-binding protein (SREBP), is a hypoxic transcription factor required for sterol homeostasis and low-oxygen growth. Nro1 regulates the stability of the N-terminal transcription factor domain of Sre1 (Sre1N) by inhibiting the action of the prolyl 4-hydroxylase-like Ofd1 in an oxygen-dependent manner. The crystal structure of Nro1 determined at 2.2 A resolution shows an all-alpha-helical fold that can be divided into two domains: a small N-terminal domain, and a larger C-terminal HEAT-repeat domain. Follow-up studies showed that Nro1 defines a new class of nuclear import adaptor that functions both in Ofd1 nuclear localization and in the oxygen-dependent inhibition of Ofd1 to control the hypoxic response.
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The hypoxic regulator of sterol synthesis nro1 is a nuclear import adaptor.,Yeh TL, Lee CY, Amzel LM, Espenshade PJ, Bianchet MA Structure. 2011 Apr 13;19(4):503-14. PMID:21481773<ref>PMID:21481773</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3msv" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cbs 356]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Amzel, L M]]
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[[Category: Schizosaccharomyces pombe]]
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[[Category: Bianchet, M A]]
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[[Category: Amzel LM]]
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[[Category: Yeh, T L]]
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[[Category: Bianchet MA]]
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[[Category: Heat repeat]]
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[[Category: Yeh TL]]
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[[Category: Helix repeat]]
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[[Category: Protein binding]]
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Current revision

The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor

PDB ID 3msv

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