3n57
From Proteopedia
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<StructureSection load='3n57' size='340' side='right'caption='[[3n57]], [[Resolution|resolution]] 3.03Å' scene=''> | <StructureSection load='3n57' size='340' side='right'caption='[[3n57]], [[Resolution|resolution]] 3.03Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3n57]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3n57]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N57 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.03Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n57 OCA], [https://pdbe.org/3n57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n57 RCSB], [https://www.ebi.ac.uk/pdbsum/3n57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n57 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n57 OCA], [https://pdbe.org/3n57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n57 RCSB], [https://www.ebi.ac.uk/pdbsum/3n57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n57 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Disease == | ||
| - | [[https://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN]] Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6) [MIM:[https://omim.org/entry/612201 612201]]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.<ref>PMID:18614783</ref> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Funke | + | [[Category: Funke T]] |
| - | [[Category: Guo | + | [[Category: Guo Q]] |
| - | [[Category: Tang | + | [[Category: Tang W-J]] |
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Current revision
Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)
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