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3nxa

From Proteopedia

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Current revision (10:01, 14 February 2024) (edit) (undo)
 
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<StructureSection load='3nxa' size='340' side='right'caption='[[3nxa]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3nxa' size='340' side='right'caption='[[3nxa]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nxa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NXA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nxa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NXA FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AAG13, S100A16, S100F ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nxa OCA], [https://pdbe.org/3nxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nxa RCSB], [https://www.ebi.ac.uk/pdbsum/3nxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nxa ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nxa OCA], [https://pdbe.org/3nxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nxa RCSB], [https://www.ebi.ac.uk/pdbsum/3nxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nxa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/S10AG_HUMAN S10AG_HUMAN]] Calcium-binding protein. Binds one calcium ion per monomer.<ref>PMID:17030513</ref>
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[https://www.uniprot.org/uniprot/S10AG_HUMAN S10AG_HUMAN] Calcium-binding protein. Binds one calcium ion per monomer.<ref>PMID:17030513</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The homodimeric structure of human S100A16 in the apo state has been obtained both in the solid state and in solution, resulting in good agreement between the structures with the exception of two loop regions. The homodimeric solution structure of human S100A16 was also calculated in the calcium(II)-bound form. Differently from most S100 proteins, the conformational rearrangement upon calcium binding is minor. This characteristic is likely to be related to the weak binding affinity of the protein for the calcium(II) ions. In turn, this is ascribed to the lack of the glutamate residue at the end of the S100-specific N-domain binding site, which in most S100 proteins provides two important side chain oxygen atoms as calcium(II) ligands. Furthermore, the presence of hydrophobic interactions stronger than for other S100 proteins, present in the closed form of S100A16 between the third and fourth helices, likely make the closed structure of the second EF-hand particularly stable, so even upon calcium(II) binding such a conformation is not disrupted.
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Structural characterization of human S100A16, a low-affinity calcium binder.,Babini E, Bertini I, Borsi V, Calderone V, Hu X, Luchinat C, Parigi G J Biol Inorg Chem. 2010 Nov 3. PMID:21046186<ref>PMID:21046186</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3nxa" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Calderone, V]]
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[[Category: Calderone V]]
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[[Category: Apo]]
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[[Category: Calcium binding protein]]
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[[Category: Ef-hand protein]]
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[[Category: Metal binding protein]]
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[[Category: Protein dynamic]]
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[[Category: S100 family]]
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[[Category: S100 protein]]
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[[Category: S100a16]]
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Current revision

X-ray structure of the apo form of human S100A16

PDB ID 3nxa

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