3obl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:04, 14 February 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='3obl' size='340' side='right'caption='[[3obl]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
<StructureSection load='3obl' size='340' side='right'caption='[[3obl]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[3obl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"planktothrix_agardhii"_emend._suda_et_al._2002 "planktothrix agardhii" emend. suda et al. 2002]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OBL FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[3obl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Planktothrix_agardhii Planktothrix agardhii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OBL FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OAA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1160 "Planktothrix agardhii" emend. Suda et al. 2002])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3obl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3obl OCA], [https://pdbe.org/3obl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3obl RCSB], [https://www.ebi.ac.uk/pdbsum/3obl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3obl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3obl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3obl OCA], [https://pdbe.org/3obl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3obl RCSB], [https://www.ebi.ac.uk/pdbsum/3obl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3obl ProSAT]</span></td></tr>
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/C0STD7_PLAAG C0STD7_PLAAG]
-
Oscillatoria agardhii agglutinin (OAA) is a recently discovered cyanobacterial lectin that exhibits potent anti-HIV activity. Up to now, only its primary structure and carbohydrate binding data have been available. To elucidate the structural basis for the antiviral mechanism of OAA, we determined the structure of this lectin by x-ray crystallography at 1.2 A resolution and mapped the specific carbohydrate recognition sites of OAA by NMR spectroscopy. The overall architecture of OAA comprises 10 beta-strands that fold into a single, compact, beta-barrel-like domain, creating a unique topology compared with all known protein structures in the Protein Data Bank. OAA sugar binding was tested against Man-9 and various disaccharide components of Man-9. Two symmetric carbohydrate-binding sites were located on the protein, and a preference for Manalpha(1-6)Man-linked sugars was found. Altogether, our structural results explain the antiviral activity OAA and add to the growing body of knowledge about antiviral lectins.
+
-
 
+
-
Novel fold and carbohydrate specificity of the potent anti-HIV cyanobacterial lectin from Oscillatoria agardhii.,Koharudin LM, Furey W, Gronenborn AM J Biol Chem. 2011 Jan 14;286(2):1588-97. Epub 2010 Oct 19. PMID:20961847<ref>PMID:20961847</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 3obl" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Planktothrix agardhii emend. suda et al. 2002]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Furey, W]]
+
[[Category: Planktothrix agardhii]]
-
[[Category: Gronenborn, A M]]
+
[[Category: Furey W]]
-
[[Category: Koharudin, L M.I]]
+
[[Category: Gronenborn AM]]
-
[[Category: Anti-hiv lectin]]
+
[[Category: Koharudin LMI]]
-
[[Category: High mannose glycan]]
+
-
[[Category: Novel beta barrel fold]]
+
-
[[Category: Sugar binding protein]]
+

Current revision

Crystal structure of the potent anti-HIV cyanobacterial lectin from Oscillatoria Agardhii

PDB ID 3obl

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3obl"
Personal tools