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5qot
From Proteopedia
(Difference between revisions)
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<StructureSection load='5qot' size='340' side='right'caption='[[5qot]], [[Resolution|resolution]] 1.68Å' scene=''> | <StructureSection load='5qot' size='340' side='right'caption='[[5qot]], [[Resolution|resolution]] 1.68Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5qot]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5qot]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QOT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QOT FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LEJ:1-(difluoromethyl)-N-[(4-fluorophenyl)methyl]-1H-pyrazole-3-carboxamide'>LEJ</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LEJ:1-(difluoromethyl)-N-[(4-fluorophenyl)methyl]-1H-pyrazole-3-carboxamide'>LEJ</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qot OCA], [https://pdbe.org/5qot PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qot RCSB], [https://www.ebi.ac.uk/pdbsum/5qot PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qot ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DCP2_HUMAN DCP2_HUMAN] Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs (PubMed:12417715, PubMed:12218187, PubMed:12923261, PubMed:21070968). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12486012, PubMed:12923261, PubMed:21070968). Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:14527413). Plays a role in replication-dependent histone mRNA degradation (PubMed:18172165). Has higher activity towards mRNAs that lack a poly(A) tail (PubMed:21070968). Has no activity towards a cap structure lacking an RNA moiety (PubMed:21070968). Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degration of their transcripts (PubMed:26098573).<ref>PMID:12218187</ref> <ref>PMID:12417715</ref> <ref>PMID:12486012</ref> <ref>PMID:12923261</ref> <ref>PMID:14527413</ref> <ref>PMID:18172165</ref> <ref>PMID:21070968</ref> <ref>PMID:26098573</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Brandao-Neto | + | [[Category: Brandao-Neto J]] |
| - | [[Category: Burgess-Brown | + | [[Category: Burgess-Brown N]] |
| - | [[Category: Collins | + | [[Category: Collins PM]] |
| - | + | [[Category: Douangamath A]] | |
| - | [[Category: Douangamath | + | [[Category: Huber K]] |
| - | [[Category: Huber | + | [[Category: Krojer T]] |
| - | [[Category: Krojer | + | [[Category: Nelson ER]] |
| - | [[Category: Nelson | + | [[Category: Talon R]] |
| - | [[Category: Talon | + | [[Category: Velupillai S]] |
| - | [[Category: Velupillai | + | [[Category: Wang D]] |
| - | [[Category: Wang | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
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Current revision
PanDDA analysis group deposition -- Crystal Structure of DCP2 (NUDT20) in complex with Z1592710382
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Brandao-Neto J | Burgess-Brown N | Collins PM | Douangamath A | Huber K | Krojer T | Nelson ER | Talon R | Velupillai S | Wang D | Von Delft F
