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1qcs

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[[Image:1qcs.jpg|left|200px]]
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{{Structure
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02933 CDC48_2], [http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam02359 CDC48_N]</span>
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{{STRUCTURE_1qcs| PDB=1qcs | SCENE= }}
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|RELATEDENTRY=[[1nsf|1nsf]], [[1d2n|1d2n]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qcs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcs OCA], [http://www.ebi.ac.uk/pdbsum/1qcs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qcs RCSB]</span>
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'''N-TERMINAL DOMAIN OF N-ETHYLMALEIMIDE SENSITIVE FACTOR (NSF)'''
'''N-TERMINAL DOMAIN OF N-ETHYLMALEIMIDE SENSITIVE FACTOR (NSF)'''
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[[Category: Jahn, R.]]
[[Category: Jahn, R.]]
[[Category: Yu, R C.]]
[[Category: Yu, R C.]]
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[[Category: double-psi beta barrel alpha beta roll]]
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[[Category: Double-psi beta barrel alpha beta roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:08:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:11:57 2008''
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Revision as of 03:08, 3 May 2008

Image:1qcs.jpg

Template:STRUCTURE 1qcs

N-TERMINAL DOMAIN OF N-ETHYLMALEIMIDE SENSITIVE FACTOR (NSF)


Overview

N-ethylmaleimide-sensitive factor (NSF) is a hexameric ATPase essential for eukaryotic vesicle fusion. Along with SNAP proteins, it disassembles cis-SNARE complexes upon ATP hydrolysis, preparing SNAREs for trans complex formation. We have determined the crystal structure of the N-terminal domain of NSF (N) to 1.9 A resolution. N contains two subdomains which form a groove that is a likely SNAP interaction site. Unexpectedly, both N subdomains are structurally similar to domains in EF-Tu. Based on this similarity, we propose a model for a large conformational change in NSF that drives SNARE complex disassembly.

About this Structure

1QCS is a Single protein structure of sequence from Cricetulus griseus. Full crystallographic information is available from OCA.

Reference

NSF N-terminal domain crystal structure: models of NSF function., Yu RC, Jahn R, Brunger AT, Mol Cell. 1999 Jul;4(1):97-107. PMID:10445031 Page seeded by OCA on Sat May 3 06:08:17 2008

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