1qcv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1qcv.jpg|left|200px]]
[[Image:1qcv.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1qcv |SIZE=350|CAPTION= <scene name='initialview01'>1qcv</scene>
+
The line below this paragraph, containing "STRUCTURE_1qcv", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1qcv| PDB=1qcv | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qcv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qcv OCA], [http://www.ebi.ac.uk/pdbsum/1qcv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qcv RCSB]</span>
+
-
}}
+
'''RUBREDOXIN VARIANT (PFRD-XC4) FOLDS WITHOUT IRON'''
'''RUBREDOXIN VARIANT (PFRD-XC4) FOLDS WITHOUT IRON'''
Line 27: Line 24:
[[Category: Mayo, S L.]]
[[Category: Mayo, S L.]]
[[Category: Strop, P.]]
[[Category: Strop, P.]]
-
[[Category: hyperthermophile]]
+
[[Category: Hyperthermophile]]
-
[[Category: rubredoxin]]
+
[[Category: Rubredoxin]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 06:08:26 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:11:57 2008''
+

Revision as of 03:08, 3 May 2008

Image:1qcv.jpg

Template:STRUCTURE 1qcv

RUBREDOXIN VARIANT (PFRD-XC4) FOLDS WITHOUT IRON


Overview

The role of surface salt bridges in protein stabilization has been a source of controversy. Here we present the NMR structure of a hyperthermophilic rubredoxin variant (PFRD-XC4) and the thermodynamic analysis of two surface salt bridges by double mutant cycles. This analysis shows that the surface side chain to side chain salt bridge between Lys 6 and Glu 49 does not stabilize PFRD-XC4. The main chain to side chain salt bridge between the N-terminus and Glu 14 was, however, found to stabilize PFRD-XC4 by 1. 5 kcal mol(-)(1). The entropic cost of making a surface salt bridge involving the protein's backbone is reduced, since the backbone has already been immobilized upon protein folding.

About this Structure

1QCV is a Single protein structure of sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA.

Reference

Contribution of surface salt bridges to protein stability., Strop P, Mayo SL, Biochemistry. 2000 Feb 15;39(6):1251-5. PMID:10684603 Page seeded by OCA on Sat May 3 06:08:26 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1qcv"
Personal tools