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8btn
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of BcThsB== | |
| - | + | <StructureSection load='8btn' size='340' side='right'caption='[[8btn]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8btn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus_MSX-D12 Bacillus cereus MSX-D12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BTN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8btn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8btn OCA], [https://pdbe.org/8btn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8btn RCSB], [https://www.ebi.ac.uk/pdbsum/8btn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8btn ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/THSB2_BACCS THSB2_BACCS] TIR-like domain-containing component of the Thoeris antiviral defense system, composed of ThsA and ThsB and ThsB' (Probable). In the presence of NAD(+) produces a signaling molecule that activates cognate ThsA (AC J8G6Z1) to hydrolyze NAD(+) (PubMed:36174646). The signaling molecule is a cyclic ADP-D-ribose isomer and may be 3' cyclic ADP-D-ribose (3'cADPR); it is not 2'cADPR (Probable).<ref>PMID:36174646</ref> <ref>PMID:36174646</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bacillus cereus MSX-D12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sabonis D]] | ||
| + | [[Category: Tamulaitiene G]] | ||
Current revision
Crystal structure of BcThsB
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